My research interests lie in how computational approaches can be used to understand the relationship between protein sequence, protein structure and biological function and disease. My research has focused on many aspects of computational structural bioinformatics, including both the development of new algorithms and the application of these techniques to predict the effect genetic sequence variations have on the structure, dynamics, folding and function of proteins and their involvement in the onset and proliferation of disease. I am currently applying these aprroaches to strain variation in the Influenza virus and other infectious diseases.